This impacted Europeans and Native Americans positively with the new materials now available like technology plants and animals. Syphilis disease also passed to the Europeans. Justinian Code Matching Activity Byzantine Empire Roman Republic 12 Tables In 2022 Coding World History Lessons Student Reading Negative effects of Columbian Exchange One of the major negative effects seen by the Columbian Exchange was the spreading of disease. . The Columbian Exchange had both negative and positive effects. The following composition states and supports the idea that the Columbian Exchange resulted in more positive effects rather than negatives in the scope of foods and diseases between Afro-Eurasia and the Americas because of the newly added varieties of crops and animals for food traded by the Europeans and the Amerindians. Europeans brought deadly viruses and bacteria such as smallpox measles typhus and cholera for which Native Americans had no im...